CURE Trial
(Last Updated - 6/21/2007)
"Effects Of Clopidogrel In Addition To Aspirin In Patients With Acute Coronary Syndromes Without ST-Segment Elevation"
NEJM: 8/16/2001 - Volume 345(7): Pages 494-502.
-Plavix 300 initial load then 75 QDay & Aspirin vs. Placebo & Aspirin
-Primary Outcomes:
1) Death from CV cause
2) Non-fatal MI
3) CVA
-9.3% w/ Plavix vs. 11.4% w/ Placebo --> 2.1% difference (benefit)
-Secondary Outcome:
-Refractory Ischemia
16.5% w/ Plavix vs. 18.8% w/ placebo --> 2.3% difference (benefit)
-Side Effex:
-Major bleeding
-3.7% w/ Plavix vs. 2.7% w/ placebo --> 1.0% difference (risk)
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